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Richard A Flavell Selected Research

Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

11/2011Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A.
3/2009B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis.
1/2009Induction of hepatitis by JNK-mediated expression of TNF-alpha.
6/2008Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice.
3/2008An antibiotic-responsive mouse model of fulminant ulcerative colitis.
7/2007Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
2/2006Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses.
3/2004The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.
8/2003Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
5/2003TNF-alpha impairs peripheral tolerance towards beta-cells, and local costimulation by B7.1 enhances the effector function of diabetogenic T cells.

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Richard A Flavell Research Topics

Disease

87Inflammation (Inflammations)
02/2024 - 11/2002
80Infections
01/2023 - 06/2002
53Neoplasms (Cancer)
10/2023 - 03/2002
32Colitis
04/2024 - 02/2002
21Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
02/2024 - 04/2006
21Autoimmune Diseases (Autoimmune Disease)
01/2021 - 12/2002
18Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2023 - 08/2002
17Virus Diseases (Viral Diseases)
01/2023 - 03/2004
13Asthma (Bronchial Asthma)
01/2022 - 01/2002
11Fibrosis (Cirrhosis)
12/2023 - 12/2002
11Ischemia
10/2023 - 11/2002
10Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
01/2023 - 08/2002
10Carcinogenesis
10/2020 - 08/2003
9Obesity
01/2023 - 10/2007
9Pneumonia (Pneumonitis)
04/2022 - 01/2002
9Insulin Resistance
01/2022 - 03/2004
9Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2016 - 06/2003
8Arthritis (Polyarthritis)
01/2022 - 06/2002
7Lung Injury
10/2023 - 01/2003
7Melanoma (Melanoma, Malignant)
01/2023 - 05/2006
7Atherosclerosis
10/2014 - 11/2003
7Encephalitis (Encephalitis, Rasmussen)
01/2012 - 12/2004
6Hypersensitivity (Allergy)
01/2021 - 02/2002
6Bacterial Infections (Bacterial Infection)
01/2019 - 07/2002
6West Nile Fever
01/2017 - 12/2004
6Necrosis
02/2012 - 02/2003
5Colorectal Neoplasms (Colorectal Cancer)
12/2023 - 06/2011
5Psoriasis (Pustulosis Palmaris et Plantaris)
01/2023 - 03/2011
5COVID-19
04/2022 - 01/2021
5Infarction (Infarctions)
11/2021 - 11/2002
5Disease Progression
01/2021 - 05/2005
5Alzheimer Disease (Alzheimer's Disease)
06/2008 - 12/2002
4Non-alcoholic Fatty Liver Disease
09/2023 - 02/2012
4Neuroinflammatory Diseases
01/2022 - 09/2006
4Lymphopenia (Lymphocytopenia)
01/2022 - 05/2010
4Dysbiosis
01/2021 - 02/2012
4Ulcerative Colitis
01/2021 - 03/2008
4Human Influenza (Influenza)
04/2016 - 12/2004

Drug/Important Bio-Agent (IBA)

80CytokinesIBA
12/2023 - 01/2002
43InflammasomesIBA
01/2023 - 06/2006
38Proteins (Proteins, Gene)FDA Link
04/2024 - 03/2002
29Interleukin-10 (Interleukin 10)IBA
02/2024 - 02/2006
25Transforming Growth Factor beta (TGF-beta)IBA
12/2013 - 06/2002
21Toll-Like Receptors (Toll-Like Receptor)IBA
01/2015 - 07/2002
20Interleukin-17 (Interleukin 17)IBA
07/2023 - 03/2003
19AntigensIBA
01/2023 - 12/2002
17Interleukin-18 (Interleukin 18)IBA
12/2022 - 02/2004
15Interleukin-22 (IL-22)IBA
10/2023 - 10/2007
13Phosphotransferases (Kinase)IBA
01/2021 - 06/2002
13Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
12/2013 - 09/2003
11AntibodiesIBA
12/2023 - 06/2003
11RNA (Ribonucleic Acid)IBA
10/2023 - 12/2004
11p38 Mitogen-Activated Protein KinasesIBA
10/2023 - 06/2002
11LigandsIBA
01/2023 - 05/2004
11Messenger RNA (mRNA)IBA
01/2022 - 03/2002
10Interleukin-6 (Interleukin 6)IBA
12/2023 - 02/2006
10Antiviral Agents (Antivirals)IBA
01/2022 - 12/2004
10Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2011 - 05/2003
9InterferonsIBA
12/2023 - 04/2009
96-methyladenineIBA
10/2023 - 08/2018
9InterleukinsIBA
10/2023 - 06/2006
9Interleukin-9 (Interleukin 9)IBA
01/2022 - 01/2002
8Insulin (Novolin)FDA Link
12/2022 - 08/2002
8AutoantigensIBA
01/2016 - 12/2002
7Caspase 3 (Caspase-3)IBA
10/2023 - 01/2003
7Glucose (Dextrose)FDA LinkGeneric
01/2022 - 11/2002
7Mitogen-Activated Protein KinasesIBA
06/2019 - 03/2003
7DNA (Deoxyribonucleic Acid)IBA
01/2017 - 03/2003
7AutoantibodiesIBA
01/2016 - 09/2006
6LipidsIBA
09/2023 - 02/2006
6Dextrans (Dextran)FDA Link
01/2023 - 12/2010
6sodium sulfate (sodium bisulfate)FDA LinkGeneric
01/2023 - 12/2010
6VaccinesIBA
01/2023 - 07/2009
6Oxygen (Dioxygen)IBA
01/2019 - 11/2002
6NLR ProteinsIBA
06/2013 - 08/2009
6Interleukin-12 (IL 12)IBA
04/2009 - 02/2004
5Transcription Factors (Transcription Factor)IBA
02/2024 - 08/2007
5CollagenIBA
12/2023 - 03/2003
5EnzymesIBA
10/2023 - 01/2022
5ChemokinesIBA
06/2021 - 01/2007
5Interleukin-23 (Interleukin 23)IBA
01/2021 - 11/2006
5Interleukin-4 (Interleukin 4)IBA
01/2021 - 01/2002
5Interleukin-13IBA
01/2016 - 01/2002
5Transforming Growth Factors (Transforming Growth Factor)IBA
07/2013 - 09/2003
5Toll-Like Receptor 3IBA
11/2012 - 05/2004
5Double-Stranded RNA (RNA, Double Stranded)IBA
11/2012 - 05/2004
5Interleukin-1 Receptor-Associated KinasesIBA
09/2012 - 09/2006
5Poly I-CIBA
02/2011 - 03/2006
5Amyloid beta-PeptidesIBA
06/2008 - 12/2002
5Transforming Growth Factor beta1 (TGF beta 1)IBA
05/2007 - 12/2002
5CaspasesIBA
06/2005 - 03/2002
4Interleukin-10 ReceptorsIBA
12/2023 - 01/2011
4Carbon MonoxideIBA
10/2023 - 01/2003
4Interferon Type IIBA
01/2023 - 04/2009
4Viral RNAIBA
04/2022 - 06/2012
4Interferon-gamma (Interferon, gamma)IBA
01/2022 - 06/2005
4Immunoglobulin E (IgE)IBA
01/2021 - 01/2009
4Protein Isoforms (Isoforms)IBA
02/2016 - 03/2002

Therapy/Procedure

25Therapeutics
01/2023 - 03/2003
13Immunotherapy
12/2023 - 05/2004